Repositorium
Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants
bearbeiten
173
Typ / Jahr
Journal Article / 2016
Autoren
Qi, Yiping; Zhang, Yong; Baller, Joshua A.; Voytas, Daniel F.
Abstract
Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana.
Keywords
Arabidopsis thaliana; DNA double-strand break (DSB) repair; H2AX; Small RNA; zinc finger nuclease (ZFN)
Periodical
Mutation research
Periodical Number
Page range
9–14
Volume
783
DOI
10.1016/j.mrfmmm.2015.12.002
Techniques
ID | Corresponding Author Country |
Plant Species | GE Technique Sequence Identifier |
Trait Type of Alteration |
Progress in Research Key Topic |
---|---|---|---|---|---|
373 |
Qi, Yiping USA |
Arabidopsis thaliana |
Zinc-finger nucleases ADH1 |
Allyl alcohol resistance SDN1 |
Basic research Basic research |
374 |
Qi, Yiping USA |
Arabidopsis thaliana |
Zinc-finger nucleases ADH1 |
Allyl alcohol resistance SDN3 |
Basic research Basic research |